ד"ר וייץ איריס

ד"ר וייץ איריס

Dr. Iris Sonia Weitz

ד"ר וייץ איריס
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Department
Biotechnology Engineering
Research Interests

Nanochemistry, Functional nanomaterials

Functionalized nanoparticulate systems are used for a variety of medical and pharmaceutical applications, as they are mainly considered ideal carriers for drug delivery and diagnostic agents.

In my research laboratory at the Department of Biotechnology Engineering at ORT Braude College, I combine broad-based knowledge of synthetic organic chemistry with nanotechnology tools to manipulate materials and their properties at the nanoscale level for therapeutic purposes.

My current research activities are focused on the following areas:

  1. Design and synthesis of contrast enhancing materials for dual-modality imaging based on copper oxide nanoparticles and gold-copper alloy nanoparticles. This research has the potential to influence a variety of fields, including early cancer detection, leading to a new class of multifunctional nanoparticles.
  2. Study different drug encapsulation strategies that will trigger a localized release of copper-based nanoparticles by focused ultrasound beam.
  3. Treatment of candida infections by combination therapy of two drugs with different mechanism actions (i.e., copper oxide nanoparticles and small bioactive-organic molecules) as an important strategy in the management of difficult-to-treat fungal infections.

 

Courses
  • General and Analytical Chemistry
  • Organic Chemistry 2
  • Organic Chemistry (Lab course)
  • Chemistry of Materials
  • Medicinal Chemistry (Lab course)

 

Contact Information
Email
irisweitz@braude.ac.il
Telephone
972-4-990-1895
Office
D-215
Education
Ph.D. 1997,

Medicinal Chemistry, Department of Medicinal Chemistry and Natural Products, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, Israel

M.Sc. 1991,
Organic Chemistry, Department of Organic Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
B.Sc. 1989,
Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
Research Areas

Nanochemistry, Functional nanomaterials

Functionalized nanoparticulate systems are used for a variety of medical and pharmaceutical applications, as they are mainly considered ideal carriers for drug delivery and diagnostic agents.

In my research laboratory at the Department of Biotechnology Engineering at ORT Braude College, I combine broad-based knowledge of synthetic organic chemistry with nanotechnology tools to manipulate materials and their properties at the nanoscale level for therapeutic purposes.

My current research activities are focused on the following areas:

  1. Design and synthesis of contrast enhancing materials (CEM) for dual-modality imaging based on copper oxide nanoparticles and gold-copper alloy nanoparticles. This research has the potential to influence a variety of fields, including early cancer detection, leading to a new class of multifunctional nanoparticles.
  2. Study different drug encapsulation strategies that will trigger a localized release of copper-based nanoparticles by focused ultrasound beam.
  3. Treatment of candida infections by combination therapy of two drugs with different mechanism actions (i.e., copper oxide nanoparticles and small bioactive-organic molecules) as an important strategy in the management of difficult-to-treat fungal infections.

 

Academic Appointments
2015-present Senior Lecturer, Department of Biotechnology Engineering, ORT Braude College, Karmiel, Israel

2011-2015 Lecturer, Department of Biotechnology Engineering, ORT Braude College, Karmiel, Israel

2007-2011 Lecturer (special contract), Department of Biotechnology Engineering, ORT Braude College, Karmiel, Israel

2002-2007  Adjunct Lecturer, Department of Biotechnology Engineering, ORT Braude College, Karmiel, Israel

2005-2007 Adjunct Lecturer, Open University, Beit Biram, Haifa, Israel 

1997-1999 Post-doctoral Fellow, Department of Chemistry and Biochemistry, University of California at Los Angeles (UCLA), Los-Angeles, CA, USA In collaboration with Professor J. R. Heath 

1992-1997 Research Assistant, Department of Medicinal Chemistry and Natural Products, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, Israel

Teaching Experience
Courses for engineering students, ORT Braude College
Organic Chemistry 2, General and Analytical Chemistry, Chemistry of Materials and Medicinal Chemistry Laboratory (combinatorial chemistry)
Academic and Professional Awards and Grants

1995       School of Pharmacy Award for outstanding Ph.D. research

1997       Faculty of Medicine Award for excellent Ph.D. thesis (Dean’s award)

Professional Activities

2002-2005 Developed courses in the field of Medicinal  Chemistry at the Ministry of Industry, Trade and Labor, The Governmental Institute for Training in Technology and Science (GITTS)

2011 – 2014 Member of College Strategy Committee, ORT Braude College

2007 – 2018 Coordinator at Internship Students Program, ORT Braude College

2012 – present Academic advisor for students, Department of Biotechnology Engineering 

2012 – present  Member of Student Excellence College Committee, ORT Braude College

2012 – present Member of Research Committee, Department of Biotechnology Engineering

2012 – present Member, Curriculum Committee, Department of Biotechnology Engineering

 
Publications
Refereed Papers
  1. O. Perlman, I. S. Weitz, S. S. Sivan, H. Abu-Khalla, M. Benguigui, Y. Shaked and H. Azhari, Copper oxide loaded PLGA nanospheres: Towards a multifunctional nanoscale platform for ultrasound-based imaging and therapy. Nanotechnology 29 (18) 185102, 2018
  2. O. Perlman, I. S. Weitz, and H. Azhari, Target visualisation and microwave hyperthermia monitoring using nanoparticle-enhanced transmission ultrasound (NETUS). International Journal of Hyperthermia, 24 1, 2017  
  3. I. S. Weitz, M. Maoz, D. Panitz, S. Eichler, E. Segal, Combination of CuO nanoparticles and fluconazole: preparation, characterization, and antifungal activity against Candida albicans. Journal of Nanoparticle Research 17 (342) 1-9, 2015
  4. O. Perlman, I. S. Weitz, and H. Azhari, Copper Oxide Nanoparticles as Contrast Agents for MRI and Ultrasound Dual-Modality Imaging. Physics in Medicine and Biology 60, 5767-5783, 2015
  5. I. S. Weitz J. L. Sample, R. Ries, E. M. Spain, and J. R. Heath, Josephson Coupled Quantum Dot Artificial Solids, Journal of Physical Chemistry B 104, 4288-4291, 2000
  6. C.-Y. Liu, A. J. Bard, F. Wudl, I. S. Weitz and J. R. Heath, Electrochemical Characterization of Films of Single-Walled Carbon Nanotubes and Their Possible Application in Supercapacitors, Electrochemical and Solid-State Letters 2, 577-578, 1999
  7.  I. S. Weitz, M. Pellegrini, M. Royo, D. F. Mierke and M. Chorev, 1,2,5-Trisubstituted 1, 4-Diazepine-3-one: A Novel Dipeptidomimetic Molecular Scaffold, Letters in Peptide Science 5, 83-86, 1998.
  8. M. Pellegrini, I. S. Weitz, M. Chorev and D. F. Mierke, Conformational Investigation of a Novel, Dipeptide Based Molecular Scaffold, Letters in Peptide Science 5, 151-153, 1998.
  9. I. S. Weitz, M. Pellegrini, D. F. Mierke and M. Chorev, Synthesis of a Trisubstituted 1,4-Diazepine-3-one-Based Dipeptidomimetic as a Novel Molecular Scaffold, Journal of Organic Chemistry 62, 2527-2534, 1997.
  10. M. Pellegrini, I. S. Weitz, M. Chorev and D. F. Mierke, A Trisubstituted 1,4-Diazepine-3-one-Based Dipeptidomimetic: Conformational Characterization by NMR and Computer Simulation, Journal of the American Chemical Society  119, 2430-2436, 1997.
  11. I. S. Weitz and M. Rabinovitz The Application of C8K for Organic Reduction of Substituted Naphthalenes. Journal of the Chemical Society Perkin Transactions I 117-120, 1993
Conference Proceedings and Abstracts

  

Conferences Proceedings

  1. O. Perlman, I.S. Weitz, and H. Azhari, Preliminary Study of Copper Oxide Nanoparticles Acoustic and Magnetic Properties for Medical Imaging. Proceedings of SPIE 9412, Medical Imaging 2015: Physics of Medical Imaging, 941204, 2015.
  2.  M. Pellegrini, I. S. Weitz, M. Chorev and D. F. Mierke, Conformational Characterization of Trisubstituted 1,-Diazepinone as a Dipeptide-Based Molecular Scaffold. Peptides: Proceedings of the 24th European Peptide Symposium, R. Ramage, R. Epton Eds. Mayflower Scientific Ltd., Kingswinford U.K. p 715-716, 1998.
  3. I. S. Weitz, M. Pellegrini, D. F. Mierke and M. Chorev, Synthesis and Characterization of a Novel Trisubstituted Hexahydro-3-Oxo 1H-1,4- Diazepine-Based Dipeptidomimetic. Unit. Peptides: Proceedings of the 24th European Peptide Symposium, R. Ramage, R. Epton Eds., Mayflower Scientific Ltd., Kingswinford U.K. p 903-904, 1998.

Invited talks

I. S. Weitz. Multifunctional Properties and Characteristics of Copper Oxide Nanoparticles. EMN Meeting on Smart and Multifunctional Materials, Berlin, Germany August 25, 2016.

 

 Abstracts of Presentations at Conferences

  1. I. S. Weitz, S. S. Sivan, O. Perlman, and H. Azhari, Encapsulation of CuO Nanoparticles by PLGA for Imaging and Controlled Delivery. The 14th Interdisciplinary Research Conference ORT Braude College, Kfar Blum in the Upper Galilee, Israel, October 17, 2018 (Oral presentation).

  2. R. Schiopu, A. Borodetsky, A. Haim, and I. S. Weitz, Noninvasive Monitoring of Ultrasound Induced CuO Nanoparticles Release From Polymeric Nano-carriers. NanoIsrael 2018, Jerusalem, October 10, 2018 (Poster)
  3. A. Borodetsky, I. Arnon, and I. S. Weitz, The Antifungal Effect of Surface Modified CuO Nanoparticles against Candida Species. NanoIsrael 2018, Jerusalem, October 10, 2018 (Poster)
  4. I. S. Weitz, O. Perlman, S. S. Sivan, and H. Azhari, Synthesis and Characterization of Copper Oxide Based Polymeric Nano-systems for Biomedical Imaging, CIMTEC 2018, 8th Forum on New Materials, Perugia, Italy, June 10, 2018 (Oral presentation).
  5.  I. S. Weitz, Synthesis and Characterization of Engineered Copper Oxide Nanoparticles and Their Medical Applications, The 13th Interdisciplinary Research Conference ORT Braude College, Nahsholim Seaside Resort, Israel, October 25, 2017 (Oral presentation).
  6. O. Perlman, I. S. Weitz and H. Azhari, Potential Medical Applications of Ultra Small Copper Oxide Nanoparticles, NanoBio&Med 2017, Barcelona Spain, November 22, 2017 (Poster).
  7.  O. Perlman, I. S. Weitz, and H. Azhari, Microwave ablation planning and monitoring using nanoparticle enhanced through-transmission ultrasound, IEEE 39th Annual International Conference of the Engineering in Medicine and Biology Society (EMBC), Jeju Island, Korea, 2017 (poster).
  8. I.S. Weitz, M. Maoz, D.Panitz, S. Eichler, and E.Segal. Studying the Therapeutic Antifungal Properties of Copper Oxide Nanoparticles. 6th Annual Symposium of Drug Delivery System 2016 (SDDS-2016), Nanjing, China, November 16, 2016 (Oral presentation)
  9. M. Tal, and I. S. Weitz, Surface modifications of copper oxide nanoparticles, The 12th Interdisciplinary Research Conference ORT Braude College, Hagoshrim, Upper Galilee, Israel, 2016 (Oral presentation)
  10. O. Perlman, I. S. Weitz and H. Azhari, Multimodal Magnetic Resonance and Through-Transmission Ultrasound Imaging of Nanoparticles, 8th HOPE Meeting with Nobel Laureates, Tsukuba, Japan, 2016 (Poster)
  11. O. Perlman, I. S. Weitz and H. Azhari, Multimodal MRI-ultrasound medical imaging of copper oxide nanoparticles, Israeli Society for Medical and Biological Engineering (ISMBE), Haifa, Israel, 2016 (Oral presentation)
  12. O. Perlman, I. S. Weitz, and H. Azhari, Investigation of copper oxide nanoparticles as a dual imaging modality contrast agent for medical diagnosis, The 11th Interdisciplinary Research Conference ORT Braude College, Hagoshrim, Upper Galilee, Israel, 2015 (Oral presentation)
  13. O. Perlman, I.S. Weitz, and H. Azhari, Copper oxide nanoparticles as contrast agents for medical imaging: a phantom study, Technion RBNI Nanotechnology Fall Symposium, Yad-Hanadiv, Israel, 2014 (Oral presentation)
  14. I. S. Weitz, M. Maoz, D. Panitz, S. Eichler, E. Segal, The Antifungal Effect of Copper Oxide Nanoparticles on Candida Albicans. The 2nd conference of The Israel Society for Biotechnology Engineering, Tel-Aviv, Israel, 2013 (Poster)
  15. M. Maoz, D. Panitz, Sigal Eichler, Ester Segal, I. S. Weitz, The Antifungal Efficacy of Formulated Copper Oxide Nanoparticles. The 9th Interdisciplinary Research Conference ORT Braude College, Hagoshrim, Upper Galilee, Israel, 2013 (Oral presentation)
  16. I. S. Weitz, M. Grozovski, M. Maoz, Copper Oxide Nano-carriers for Bioactive Drugs. The 8th Interdisciplinary Research Conference ORT Braude College, Acre, Israel, 2012 (Oral presentation)
  17. Maria Grozovski, I. S. Weitz, Paraoxonase activity and oxidative stress in experimental hypercholesterolemia. The 8th Interdisciplinary Research Conference ORT Braude College, Acre, Israel, 2012 (Oral presentation)
  18. I. S. Weitz, N. Bar-Guy and M. Grozovski, Copper oxide nanoparticles for hypercholesterolemia treatment. The 2nd International Colloids Conference, Colloids and Nanomedicine, Amsterdam, The Netherlands, 2012 (Poster)
  19. I. S. Weitz and M. Grozovski, Metal Oxide Nanoparticles as Statin Carriers. The 2nd Galil Biomedical Meeting, Tel-Hai, Israel, 2011(Oral presentation)
  20.  I. S. Weitz, N. Bar-Guy, M. Grozovski, Effect of Copper oxide nanoparticles on cholesterol levels in the liver. The 7th Interdisciplinary Research Conference ORT Braude College, Kfar Bloom, Israel, 2011(Oral presentation)
  21.  I. S. Weitz K. Knani, M. Maoz, C. Freitag, J.J. Morrell, The potential for using CuO nanoparticles as a wood preservative. IRG 42:  The International Research Group on Wood Preservation, Queenstown, New Zealand, 2011 (Oral presentation)
  22.  I. S. Weitz and M. Grozovski, Copper Oxide Nanoparticles Functionalization for Medical Applications. The 6th Interdisciplinary Research Conference ORT Braude College, Haifa, Israel, 2010 (Oral presentation)
  23.   I. S. Weitz, K. Knani and M. Maoz.  Water Soluble Copper Oxide Nanoparticles as an Antifungal Agent. The 5th Interdisciplinary Research Conference ORT Braude College, Nahariya, Israel, 2009 (Oral presentation)
  24.  M. Maoz and I. S. Weitz, M. Blumenfeld, C. Freitag, and J. J. Morrell. Antifungal Activity of Plant Derived Extracts against G. trabeum. IRG 38: The International Research Group on Wood Preservation, Grand Titon National Park, Wyoming, USA, 2007 (Oral presentation)
  25. M. Maoz and M. Blumenfeld and I. S. Weitz. Antifungal activity of plant-derived extracts against G. trabeum and T. rubrum. The 3rd Interdisciplinary Research Conference ORT Braude College, Hagoshrim, Israel, 2007 (Oral presentation)
  26. I. S. Weitz and M. Maoz, C. Freitag and J.J. Morrell, Preparation of Water-Soluble Antifungal Formulations of Hydrophobic Natural Extracts. IRG 37: The International Research Group on Wood Preservation, Tromso, Norway, 2006 (Oral presentation)
  27.  I. S. Weitz and M. Maoz, Water Soluble Antifungal Formulations of Hydrophobic Natural Extracts. The 2nd Interdisciplinary Research Conference ORT Braude College, Maalot, Israel, 2006 (Oral presentation)
  28.  I. S. Weitz and M. Maoz,  Antifungal Treatment of Wood Decay Fungi by Water Soluble Formulations of Natural Extracts. The 1st Interdisciplinary Research Conference ORT Braude College, Karmiel, Israel, 2005 (Oral presentation)
  29. I. S. Avital and M. Rabinovitz, Synthetic Applications of Potassium Graphite Intercalate, C8K, The 56th Annual Meeting of the Israeli Society Israel, Jerusalem, Israel, 1991 (Poster)
Other Publications
Theses
  1. Ph.D. thesis: Design and Synthesis of 1,4-Diazepine-3-one–Based Dipeptidomimetic as A Novel Molecular Scaffold. Supervisor: Prof. M. Chorev
  2. M.Sc. thesis: Applications of C8K for Selective Reductions of Organic Compounds. Supervisor: Prof. M. Rabinovitz